Our HPC-accelerated physics solvers excel in managing tens of thousands of intricate 3D elements, surpassing the capabilities of any other commercial solution. Physics solvers: Electromagnetics Full Wave Solvers Quasi-Static Electromagnetic Solvers Bioheat & Thermodynamics Solvers Acoustics & Wave Propagation Solvers Fluid Dynamics Solvers On top of standard engineering tools, users can seamlessly integrate custom-optimized software modules into Sim4Life.web.

Sim4Life integrates the gold standard of computable phantoms for comprehensive population coverage – the Virtual Population (ViP) human phantoms and the Virtual Zoo (ViZoo) animal phantoms. Properties: Sub-mm Resolution Hundreds of Tissues, incl. Material Properties Dynamic Tissue Models Integrated Physiological Information

The integrated tissue and physiology models within Sim4Life empower the assessment of physiological dynamic processes, e.g., for medicine and safety applications. Physiological tissue models: Electrophysiological Neuron Models Thermal Tissue Damage Model Perfusion and Thermoregulation Models Database of Tissue Properties Image-Based Heterogeneous and/or Anisotropic Properties We collaborate with researchers worldwide to collectively advance existing and introduce new tissue models.

Sim4Life provides top-tier CAD tools and versatile CAD-file importers in any format, alongside specialized tools for seamlessly integrating CAD models with anatomical models and more. Device Design Tools: 3D Spatial or 2D Planar Modeling Tools CAD Projection Tool 3D Arbitrary Object Array Generation Tool Specialized Routing Tools for Implant Lead Trajectories Volumetric and Surface Mesh Tools Automatic Head Model Segmentation Poser & Morphing Tools Computational device models can be directly validated against their physical prototype using ZMT's and SPEAG's advanced scanning platforms.

Sim4Life includes top-tier tools to convert images (e.g., T1/T2 MRI, CT) into personalized high-resolution multi-tissue models. This process integrates manual and AI-supported segmentation techniques with tissue properties assignment. Anatomical Model Generation Tools: Medical Image Segmentation Tool Set (iSEG) AI-Based Anatomical Model Generation MRI/CT Image File Importer Poser and Morphing Tools Model Registration Tools 3D Medical Diffusion Tensor Imaging (DTI) Anisotropy

Sim4Life includes a large toolbox to optimize device performance and to enhance the efficacy of therapies. From link budget and focus of thermal therapies to targeted neuromodulation and beyond, it offers scientists, engineers, and medical professionals a wide range of possibilities. List of tools: Multi-Objective Genetic Algorithm (MOGA) HyperTool Multi-Parameter Multi-Goal Optimizer Parameterized Modeling and Sweeper

We work closely with regulators to deliver regulatory grade modeling, covering standardized safety and health risk evaluations and comprehensive risk assessment workflows for MRI implant safety. Sim4Life is the ideal tool to complement clinical studies. Verified and Validated Tools: IMAnalytics with MRIxViP Libraries (MDDT qualified) Validated Evaluations of Exposure Metrics (SAR, iPD, APD, etc.) Evaluations of Tissue Temperature Increase Verified Computational Models QA and Test Suites

• Device Design Tools • Anatomical Model Generation Tools • Antenna Tools • MRI Tools • Implant Safety Tools

• User Interface • Python Scripting • High Performance Computing (HPC) • Postprocessor

The Sim4Life Framework simplifies multiphysics modeling, covering everything from problem definition and discretization to simulation, analysis, and result visualization. With the powerful Sim4Life Python API, users can automate complex workflows, including geometric modeling, simulation setup, and post-processing, while also enabling the creation of custom tools and standalone applications. Specialized tools further enhance the capabilities of Sim4Life, streamlining complex tasks and dramatically reducing user effort for advanced applications.